From Natural Bridge, Natural Bridge Station, and Glasgow Take Virginia Primary Route 130 East to U.S. 501 South at Glasgow Follow U.S. Route 501 South to Big Island. After passing the intersection of Virginia Primary Route 122, look for the Big Island Medical Center sign on the left. Proceed around the Emergency Crew Inc. building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway

From Buena Vista: Take U.S. Route 501 South to Big Island. After passing the intersection of Virginia Primary Route 122, look for the Big Island Medical Center sign on the left at the front of the Big Island Emergency Crew Inc. building. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway

From Bedford: Take Virginia Primary Route 122 North to U.S. 501 South. Turn right onto U.S. 501 South and proceed a short distance to Big Island Medical Center. Look for the Big Island Medical Center sign on the left at the front of the Big Island Emergency Crew Inc. building. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway.

From Thaxton: Take U.S. Route 460 East to the Bedford bypass and the exit to U.S. Primary Route 122 North. Take Virginia Primary Route 122 North to U.S. 501 South. Turn right onto U.S. 501 South and proceed a short distance to Big Island Medical Center. Look for the Big Island Medical Center sign on the left at the front of the Big Island Emergency Crew Inc. building. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center .The entrance is behind the railing on the covered walkway.

From Lynchburg, Boonsboro, Coleman Falls and Pearch:Take U.S. Route 501 North to Big Island. Proceed through the town of Big Island to the Big Island Emergency Crew Inc. building on the right. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway.

From Amherst and Monroe: Take U.S. Route 29 South to the intersection with Virginia Primary Route 130. Turn right onto Virginia Primary Route 130 and proceed to U.S. Route 501 South, which is past the Blue Ridge Parkway. At U.S. Route 501 South, turn left and proceed to the Big Island Emergency Crew Inc. building. You will cross under the Blue Ridge Parkway. You will pass the intersection of Virginia Primary Route 122 on the right shortly before arriving at the Big Island Emergency Crew building. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway.

From Madison Heights:
Take U.S. Route 29 North to the intersection with Virginia Primary Route 130. Turn left onto Virginia Primary Route 130 and proceed to U.S. Route 501 South, which is past the Blue Ridge Parkway. At U.S. Route 501 South, turn left and proceed to the Big Island Emergency Crew Inc. building. You will cross under the Blue Ridge Parkway. You will pass the intersection of Virginia Primary Route 122 on the right shortly before arriving at the Big Island Emergency Crew building. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway.

From Appomattox and Concord: Take U.S. Route 460 West to Lynchburg to the intersection of U.S. Route 501 North Business. Turn right on U.S. Route 501 North Business, which will join and become U.S. Route 501 North to Big Island. Proceed through the town of Big Island to the Big Island Emergency Crew Inc. building on the right. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway.

From Rustburg:Take U.S. Route 501 North Lynchburg, where it will join U.S. Route 501 North Business. U.S. Route 501 North Business will join and become U.S. Route 501 North to Big Island. Proceed through the town of Big Island to the Big Island Emergency Crew Inc. building on the right. Proceed around the Emergency Crew building on the left to the back parking lot for Big Island Medical Center. The entrance is behind the railing on the covered walkway.

From Evington: Take Virginia Primary Route 24 East to U.S. Route 29 North. Proceed on U.S. 29 North to Lynchburg and the intersection with U.S. 501 North. Turn left onto U.S. 501 North and proceed to Big Island. Proceed through the town of Big Island to the Big Island Emergency Crew Inc. building on the right. Proceed around the Emergency Crew building on the left to the back parking lot for the Big Island Medical Center.The entrance is behind the railing on the covered walkway.